Organism-wide cellular dynamics and epigenomic remodeling in mammalian aging - PubMed
4 hours ago
- #epigenomics
- #aging
- #single-cell analysis
- A single-cell chromatin accessibility atlas was created for 21 mouse tissues across three age groups and both sexes.
- Around 25% of 536 organ-specific cell types and 1828 finer-grained subtypes showed significant age-related population shifts.
- Cellular states from broadly distributed lineages exhibited synchronized dynamics with age, suggesting systemic coordination.
- Both intrinsic regulators (chromatin peaks, transcription factor activity) and extrinsic factors (cytokine programs) were identified as underlying these shifts.
- Approximately 40% of aging-associated population dynamics were sex-dependent, with thousands of peaks altered exclusively in one sex.
- The study provides a comprehensive framework for understanding how aging reshapes chromatin landscape and cellular composition across diverse tissues.