Effect of PET-MPs exposure on the toxicology of PCOS: a multi-platform computational toxicology investigation - PubMed
5 hours ago
- #PCOS
- #Computational toxicology
- #Microplastics
- PET-MPs act as endocrine-disrupting agents, potentially contributing to PCOS.
- Study integrates computational toxicology and machine learning to link PET-MP exposure to PCOS pathogenesis.
- Multi-omics analysis identified 22 overlapping genes connecting PET-MP exposure to PCOS.
- RAB9A and MAOB highlighted as potential diagnostic biomarkers influencing inflammatory responses and disrupting steroid hormone homeostasis.
- Single-cell analysis shows hub gene enrichment in ovarian granulosa cells (GCs), impacting the follicular microenvironment.
- Immune profiling indicates macrophage and γδ T cells as possible mediators of PET-MP-induced PCOS.
- Molecular docking and dynamics simulations confirm stable binding affinities of PET-MPs to RAB9A and MAOB.
- Findings suggest RAB9A and MAOB as environmental susceptibility biomarkers for PCOS development.