Fenofibrate targets PPARα-CPT1C axis to reverse aging by regulating lipid metabolism and mitochondrial function - PubMed
6 hours ago
- #PPARα
- #Fenofibrate
- #Aging
- Fenofibrate, a drug for hyperlipidemia, shows significant anti-aging effects.
- It delays systemic aging in mice models and reverses cellular senescence.
- Fenofibrate reduces age-related lipid accumulation and improves mitochondrial function.
- The anti-aging effects are mediated through PPARα activation, upregulating CPT1C.
- Fenofibrate's effects are strictly PPARα-dependent, as shown in Pparα-/- mice.
- The study suggests fenofibrate as a repurposed anti-aging therapeutic due to its safety and widespread use.
- PPARα is identified as a key regulator of aging processes, with CPT1C as a novel therapeutic target.