KLF5 controls subtype-independent highly interactive enhancers in pancreatic cancer to regulate cell survival - PubMed
5 hours ago
- #Pancreatic Cancer
- #Enhancers
- #KLF5
- KLF5 controls subtype-independent highly interactive enhancers in pancreatic cancer to regulate cell survival.
- Pancreatic ductal adenocarcinoma (PDAC) has a 5-year survival rate of 13% and is highly heterogeneous.
- Integrated chromatin accessibility and genome-wide occupancy studies identified KLF5-bound common enhancers.
- KLF5 depletion leads to decreased cell viability via apoptosis induction.
- KLF5-bound enhancers regulate target genes like the anti-apoptotic gene BCL2L1.
- Overexpression of Bcl-xL rescues apoptosis induction after KLF5 depletion.
- The study provides insights into targeting heterogeneous PDAC tumors.