Spatiotemporal profiling reveals distinct dynamics and checkpoint regulations of CAR-T and CAR-NKT cells against solid tumors - PubMed
4 hours ago
- #CAR-T cells
- #CAR-NKT cells
- #solid tumors
- CAR-T cell therapies show limited efficacy in solid tumors due to poor tumor infiltration, antigen heterogeneity, and immunosuppressive tumor microenvironments (TME).
- CAR-NKT cells are emerging as a promising alternative due to their tissue-homing ability, multi-modal cytotoxicity, and TME-modulating properties.
- Preclinical comparison revealed CAR-NKT cells outperform CAR-T cells in tumor homing, infiltration, persistence, and immune checkpoint regulation.
- CAR-T cells synergize with TIGIT blockade, while CAR-NKT cells respond better to CD96 blockade.
- The study provides insights for designing next-generation cell therapies and combination strategies for solid tumors.