An oral allopregnanolone prodrug bypasses liver metabolism via lymphatic transport enabling bioavailability in animals and humans - PubMed
6 hours ago
- #lymphatic transport
- #prodrug
- #neuroactive steroid
- An oral allopregnanolone prodrug (GlyphAllo) bypasses liver metabolism via lymphatic transport to improve bioavailability.
- The prodrug technology conjugates drugs to dietary lipids, shifting absorption to the gut lymphatic system and avoiding hepatic first-pass effects.
- In clinical trials, GlyphAllo achieved therapeutic plasma concentrations, was well tolerated, and reduced stress responses in anxiety tests.