The evolving comorbidity landscape of rheumatoid arthritis - PubMed

4 hours ago

Rheumatoid arthritis (RA) is linked to various comorbidities that significantly impact quality of life and long-term health outcomes.
Comorbidities include extra-articular manifestations, cardiovascular disease, cerebrovascular accidents, dementia, malignancy, infection, mental health disorders, and osteoporosis.
Comorbidity patterns have shifted over the past three decades, with declining prevalence of some complications but persistently high or increasing burdens of interstitial lung disease, anxiety, and depression.
Changes in the comorbidity landscape likely result from advances in RA management, such as increased use of biologic and targeted synthetic DMARDs and the adoption of treat-to-target strategies.
Clinical care is increasingly focused on comorbidity-specific epidemiology, the effects of DMARDs on comorbidity risk, and integrated approaches to address both RA and comorbid diseases.
Preventive strategies, including enhanced screening for conditions like cervical cancer, interstitial lung disease, cardiovascular disease, and osteoporosis, are crucial components of comprehensive RA management.
Awareness of evolving comorbidity trends supports more integrated and individualized care for people with RA.

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