Targeting BMP and TAZ/TEAD mechanotransduction pathways impairs acute myeloid leukemia chemoresistance - PubMed
7 hours ago
- #chemoresistance
- #AML
- #mechanotransduction
- Targeting BMP and TAZ/TEAD pathways reduces chemoresistance in acute myeloid leukemia (AML).
- BMPR1B and TAZ/TEAD levels are higher in relapsed AML patients or cytarabine/venetoclax-resistant cells.
- Mechanotransduction pathways influence AML treatment resistance due to bone marrow biomechanical changes.
- Highly confined mesenchymal stem cells express more BMP4, activating resistant AML cells.
- TAZ expression in resistant cells improves adhesion and deformability.
- A 3D bone marrow model showed that targeting BMPR1B or TAZ/TEAD with cytarabine reduces AML persistence.
- Future AML therapies may include BMPR1B and TAZ/TEAD targeting for refractory or relapsed patients.