Immunometabolic control of cytokine production by micronutrients in health, aging, and inflammation - PubMed
3 hours ago
- #immunometabolism
- #cytokine regulation
- #micronutrients
- Micronutrients act as metabolic sensors and epigenetic regulators, controlling cytokine production across five levels: nutrient sensing, transcriptional control, redox signaling, pyroptosis/ferroptosis execution, and metabolic bioenergetics.
- Specific micronutrient roles include vitamin D suppressing IL-22 via VDREs, zinc-metallothionein-3 modulating inflammasome activation, selenium stabilizing calcium entry in immune cells, and folate tuning epigenetic landscapes through SAM.
- The review highlights integrated mechanisms linking micronutrient availability to immunometabolic checkpoints, with implications for nutritional immunotherapy in chronic inflammatory diseases and immune-senescence.