Sanhua essential oil exerts antidepressant effects in breast cancer-related depression by modulating metabolic pathways - PubMed
11 hours ago
- #Sanhua essential oil
- #Breast cancer-related depression
- #Spatial metabolomics
- Sanhua essential oil (SEO) shows potential antidepressant effects in breast cancer-related depression (BCRD).
- SEO improves depressive-like behaviors in BCRD mice, comparable to fluoxetine.
- Metabolomic analysis identified six differential metabolites affected by SEO.
- SEO enhances perfusion and functional recovery in hippocampal subregions (CA1, CA2, CA3, DG).
- GC-MS identified 31 bioactive components in SEO, with eugenol and 2-phenylethanol as dominant constituents.
- Eugenol and 2-phenylethanol are key brain-penetrant components of SEO.
- SEO modulates hippocampus-centered metabolic and functional networks.
- ALOX15 inhibition and CAII improvement are the main molecular mechanisms of SEO's effects.