Functional and effective connectivity disruptions of the dopaminergic reward circuit in multiple sclerosis patients with depression - PubMed
6 hours ago
- #depression
- #multiple sclerosis
- #reward circuit
- Depression in multiple sclerosis (MS) patients may be linked to disruptions in the dopaminergic reward circuit.
- The study compared functional connectivity (FC) in MS patients with depression (MS-D), without depression (MS-nD), and major depressive disorder (MDD) patients without MS.
- MS-D patients showed reduced FC compared to both MS-nD and MDD groups, indicating dysfunction in the reward circuit.
- Dynamic causal modeling (DCM) revealed inhibitory self-connections and negative modulation in the VTA and NAcc regions in MS-D patients.
- The findings suggest FC and EC investigations could serve as non-invasive biomarkers for understanding depression in MS and aid in personalized therapy development.