Insights into the potential pathogenesis and therapeutic implications of ferroptosis in brain microvascular endothelial cells during stroke - PubMed
5 hours ago
- #stroke
- #blood-brain barrier
- #ferroptosis
- Ferroptosis, an iron-dependent cell death pathway, plays a key role in stroke-related brain injury.
- Brain microvascular endothelial cells (BMECs) are crucial for Blood-Brain Barrier (BBB) integrity.
- BMEC ferroptosis contributes to stroke pathogenesis by compromising BBB, causing edema, and increasing neuroinflammation.
- Key signaling pathways like Meg3/p53/GPX4 and TEAD1/MMP3 regulate BMEC ferroptosis.
- Therapeutic strategies include iron chelators, genetic interventions, nanodelivery systems, and selenium compounds.
- The study aims to provide insights for neuroprotective therapies targeting BMEC ferroptosis in stroke.