Alzheimer's Disease, Circadian Rhythms, and the Immune System: Potential Interconnections - PubMed
6 hours ago
- #Alzheimer's Disease
- #Neuroinflammation
- #Circadian Rhythms
- Alzheimer's disease (AD) is a prevalent neurodegenerative disorder characterized by amyloid-β plaques and neurofibrillary tangles.
- Circadian rhythm disruptions (chronodisruption) are linked to AD pathogenesis, affecting metabolism, sleep, and neuroinflammation.
- The immune system, including microglia and astrocytes, plays a central role in AD progression.
- Immune function exhibits circadian variation, and disruptions may impair amyloid-β clearance and promote inflammation.
- Potential therapeutic strategies include melatonin agonists, orexin receptor antagonists, and lifestyle interventions like the Mediterranean diet and physical activity.
- The gut microbiome, influenced by circadian rhythms, may contribute to AD pathophysiology.
- Bidirectional interactions between immune signaling and circadian rhythms highlight a complex regulatory network in AD.