Kakkalide promotes spinal cord injury repair by regulating microglial M2 polarization via mitophagy - PubMed
a day ago
- #Spinal cord injury
- #Microglia
- #Kakkalide
- Kakkalide, a natural isoflavone, promotes spinal cord injury (SCI) repair by regulating microglial M2 polarization via mitophagy.
- The study found that kakkalide reduces secondary inflammation and improves locomotor recovery in SCI mice.
- In vitro, kakkalide shifts microglia from pro-inflammatory M1-like to anti-inflammatory M2-like phenotypes.
- Mechanistically, kakkalide activates BNIP3/NIX-dependent mitophagy, restoring mitochondrial homeostasis and reducing mtROS accumulation.
- Sirtuin 3 (SIRT3) was identified as a direct target of kakkalide, essential for its neuroprotective effects.
- Inhibition of SIRT3 with 3-TYP negates kakkalide's benefits, confirming the SIRT3-mitophagy axis as a therapeutic target.