Photosynthetic Nanobacteria Drive Metabolic-Immune Synergy for Hypoxia-Resistant Cancer Therapy - PubMed
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- #immunotherapy
- #metabolic intervention
- #photodynamic therapy
- Development of a multifunctional photosynthetic nanoplatform (PnanoCB) derived from Microcystis wesenbergii for cancer therapy.
- PnanoCB retains photosynthetic capacity and chlorophyll, functionalized with an MMP-2-cleavable anti-PD-L1 peptide for targeted immune checkpoint blockade.
- PnanoCB generates oxygen in situ under red light irradiation, overcoming tumor hypoxia and enhancing PDT efficacy.
- Combination with a fasting-mimicking diet (FMD) improves tumor accumulation and therapeutic outcomes.
- Significant tumor inhibition in 4T1 breast cancer model and prevention of tumor recurrence without major organ toxicity.
- Activation of the STING pathway promotes dendritic cell maturation and robust systemic antitumor immunity.