CircTHBS1 stabilizes N-acetyltransferase 10 to promote N4-acetylcytidine-dependent Rab8a translation and autophagy in esophageal squamous cell carcinoma - PubMed
5 hours ago
- #Esophageal squamous cell carcinoma
- #Autophagy
- #RNA acetylation
- CircTHBS1 promotes autophagy and progression in esophageal squamous cell carcinoma (ESCC).
- CircTHBS1 stabilizes N-acetyltransferase 10 (NAT10), preventing its degradation and increasing N4-acetylcytidine (ac4C) modification.
- Rab8a is a key target of ac4C modification, enhancing its translation and driving autophagy.
- Disruption of ac4C modification impairs Rab8a-driven autophagy and suppresses tumor progression.
- The study identifies a circTHBS1/NAT10-ac4C/Rab8a axis as a potential therapeutic target for ESCC.