Monoclonal antibodies from COVID-19 convalescent patients target cryptic epitopes for broad SARS-CoV-2 neutralization - PubMed
5 hours ago
- #neutralizing antibodies
- #COVID-19
- #SARS-CoV-2
- Monoclonal antibodies (mAbs) TAU-1109 and TAU-2310 were isolated from COVID-19 convalescent patients.
- These mAbs target highly conserved non-receptor-binding motif epitopes on SARS-CoV-2 spike protein.
- The mAbs exhibit broad neutralizing activity against all circulating variants of concern (VOCs), including Omicron subvariants.
- Neutralization mechanism involves destabilization of the spike trimer, leading to premature shedding of the S1 subunit.
- Study provides insights for developing universal therapeutic antibodies and vaccines against COVID-19.