Programmed cell death network in cancer drug resistance: A framework for therapeutic intervention - PubMed
4 days ago
- #Cancer
- #Programmed Cell Death
- #Drug Resistance
- Cancer drug resistance is a major challenge in treatment, often due to evasion of programmed cell death (PCD).
- Six PCD modalities are discussed: apoptosis, necroptosis, pyroptosis, autophagy, ferroptosis, and cuproptosis.
- PANoptosis links apoptosis, necroptosis, and pyroptosis; ferroptosis and cuproptosis share redox circuitry.
- Immunogenic cell death interacts bidirectionally with the tumor microenvironment.
- Single-agent interventions are often insufficient; synergistic, multitarget strategies are proposed.
- Emerging tools include single-cell omics, AI modeling, CRISPR screening, and nanoparticle delivery.
- Future research should focus on holistic PCD views, biomarkers, and combination therapies to overcome resistance.