Prednisolone Once Daily vs Hydrocortisone Thrice Daily in Hypoadrenalism: A Randomized Clinical Trial - PubMed
5 hours ago
- #Prednisolone
- #Adrenal Insufficiency
- #Hydrocortisone
- The study compares once-daily low-dose prednisolone with thrice-daily hydrocortisone for treating adrenal insufficiency.
- Primary outcome: Prednisolone significantly slowed bone turnover compared to hydrocortisone, evidenced by lower levels of bone markers like carboxylated osteocalcin.
- Secondary outcomes: Prednisolone led to greater reductions in weight, BMI, waist circumference, and HbA1c compared to hydrocortisone.
- No differences were found in safety measures or subjective health outcomes between the two treatments.
- Conclusion: Once-daily prednisolone improves bone and cardiometabolic health without compromising well-being, suggesting it as a viable alternative to hydrocortisone.