Bortezomib Induces Apoptosis via Upregulation of Abhd4 in Peripheral Nerve Cells - PubMed
6 hours ago
- #Abhd4
- #peripheral-neuropathy
- #bortezomib
- Bortezomib, a proteasome inhibitor, is used to treat multiple myeloma but causes peripheral neuropathy (PN) in 20-30% of patients.
- The study compared bortezomib and carfilzomib effects on peripheral nerve cells to identify molecules involved in PN development.
- Bortezomib selectively upregulated α/β-hydrolase containing domain 4 (Abhd4) in differentiated F11 cells, unlike carfilzomib.
- Abhd4 overexpression promoted early apoptosis, linking bortezomib-induced Abhd4 elevation to neuronal vulnerability.
- Abhd4 is a candidate molecular signature for bortezomib-induced PN, warranting further investigation.