SESN2 suppresses ferroptosis in polycystic ovary syndrome by maintaining PRDX6 K209 lactylation - PubMed
7 hours ago
- #PCOS
- #ferroptosis
- #lactylation
- SESN2 protects against ferroptosis in polycystic ovary syndrome (PCOS) by preserving PRDX6 lactylation at the K209 site.
- In PCOS models, SESN2 deficiency increases oxidative stress and ferroptosis in ovarian granulosa cells.
- PRDX6 interacts with GPX4, and this interaction is weakened by the K209R mutation, impairing redox homeostasis.
- Re-expression of wild-type PRDX6, but not the K209R mutant, mitigates oxidative stress and ferroptotic injury caused by SESN2 deficiency.
- The SESN2-PRDX6 pathway is highlighted as a potential therapeutic target for PCOS.