Fc-fucosylation of Plasmodium falciparum-specific IgG varies with antigen and immunization - PubMed
5 hours ago
- #malaria
- #IgG
- #Fc-fucosylation
- Fc-fucosylation of IgG impacts NK cell-mediated ADCC, with afucosylation enhancing this function.
- Antigens on host-derived membranes (like PfEMP1 on infected erythrocytes) induce Fc-afucosylated IgG, unlike parasite membrane antigens.
- In naturally exposed children, IgG against PfEMP1 and PfGARP (putative surface antigens) were afucosylated, while other parasite antigens induced fully fucosylated IgG.
- Vaccination with recombinant proteins (MSP1, Pfs230, CSP) consistently induced fully fucosylated IgG in adults.
- Children with afucosylated PfGARP-specific IgG had lower risk of P. falciparum carriage, independent of IgG levels.
- Fc-afucosylation is driven by antigen exposure context (host membranes), with host factors playing a minor role.