ZMAT1 Promotes Osteoclastogenesis Through TRIM46 Mediated YAP1 Degradation and Inhibits Osteoblastogenesis - PubMed
5 hours ago
- #osteoclastogenesis
- #osteoblastogenesis
- #ubiquitination
- ZMAT1 promotes osteoclastogenesis and inhibits osteoblastogenesis.
- ZMAT1 deficiency reduces osteoclast activity and bone resorption.
- ZMAT1 acts as a transcriptional repressor of TRIM46, an E3 ubiquitin ligase.
- TRIM46 regulates YAP1 degradation via K48-linked ubiquitination.
- ZMAT1 deficiency enhances osteoblast activity and bone formation.
- The study identifies a novel ZMAT1/TRIM46/YAP1 regulatory axis.
- Findings suggest potential therapeutic targets for osteoporosis.