Dysbiosis of the nasal microbiome is associated with prospective acute exacerbation of COPD - PubMed
6 hours ago
- #AECOPD
- #Microbiome
- #COPD
- Dysbiosis of the nasal microbiome is linked to acute exacerbation of COPD (AECOPD).
- The study involved 41 COPD patients and 15 healthy controls, analyzing nasal microbiome composition.
- Two distinct nasal microbiome architectures were identified: a 'healthy signature' with protective taxa and a 'pathogenic signature' with pathobionts.
- COPD patients with prior AECOPD had significantly different nasal microbiomes compared to healthy controls.
- Participants with reduced nasal Dolosigranulum pigrum abundance had lower lung function and higher risk of future AECOPD.
- Findings suggest D. pigrum could serve as a biomarker for AECOPD risk, but further validation is needed.