Beyond bystanders: How β cell stress shapes the autoimmune response in T1D - PubMed

5 hours ago

Research on type 1 diabetes (T1D) has traditionally focused on the immune system's role, but new evidence highlights the importance of intrinsic pancreatic β cell defects, especially impaired stress responses.
Immune-targeting therapies have shown limited success, only delaying T1D rather than preventing or curing it, suggesting a need for alternative approaches.
The article explores why the immune system targets β cells, how stress pathways affect β cell-immune cell interactions, and the concept of β cell resilience.
Challenges and opportunities in targeting β cell stress as a therapeutic strategy for T1D are discussed.

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