Engineering Silk Fibroin-Based Biomaterials for Neural Repair - PubMed
4 hours ago
- #neural regeneration
- #biomaterials
- #silk fibroin
- Silk fibroin (SF) is a natural protein biomaterial with tunable mechanical properties, controllable degradation, and modification potential, making it suitable for neural repair.
- SF-based biomaterials actively regulate axonal guidance, neural and glial cell behavior, and neuroinflammatory responses, beyond just serving as passive scaffolds.
- Various formats of SF-based materials include hydrogels, scaffolds, patches, nanofibers, and nerve conduits for applications in peripheral nerve injury and CNS disorders.
- Applications of SF biomaterials extend to conditions like spinal cord injury, traumatic brain injury, cerebral palsy, ischemic stroke, and Parkinson's disease.
- Challenges and future perspectives focus on guiding the design and clinical translation of next-generation neural repair strategies.