Antisense oligonucleotide inhibition of HMGB1 attenuates angiotensin II-induced abdominal aortic aneurysms - PubMed
2 days ago
- #Antisense Oligonucleotide
- #Abdominal Aortic Aneurysm
- #HMGB1
- HMGB1 plays a significant role in the pathogenesis of abdominal aortic aneurysms (AAA).
- Transcriptomic analysis showed upregulation of HMGB1 in both human and mouse aneurysmal tissue.
- Angiotensin II (AngII) infusion increased HMGB1 protein levels in the abdominal aorta of mice.
- Antisense oligonucleotide (ASO) inhibition of HMGB1 significantly reduced AngII-induced AAA formation.
- HMGB1 ASO therapy did not affect blood pressure, highlighting its potential as a targeted treatment for AAA.