Calcined lotus leaf-derived carbon dots: enhanced hemostasis, anti-inflammatory, immunomodulatory properties for ulcerative colitis management - PubMed
6 hours ago
- #carbon dots
- #anti-inflammatory
- #ulcerative colitis
- Calcined lotus leaf-derived carbon dots (LLC) show potential for managing ulcerative colitis (UC) through multiple mechanisms.
- LLC exhibits dose-dependent hemostatic effects, increasing platelet count and fibrinogen concentration while shortening clotting times.
- LLC demonstrates strong antioxidant properties, scavenging free radicals like DPPH•, ABTS+•, •OH, and O2-•.
- In a DSS-induced UC mouse model, LLC alleviates symptoms, reduces inflammation, and improves colonic health.
- LLC downregulates pro-inflammatory cytokines (TNF-α, IL-6) and oxidative stress markers (ROS, MDA).
- LLC inhibits pyroptosis by suppressing the NLRP3/Caspase-1/GSDMD signaling pathway.
- LLC modulates immune responses by balancing CD4+/CD8+ T cells and Th17/Treg ratios.
- LLC promotes intestinal barrier repair by upregulating tight junction proteins (Claudin-1, Occludin).
- LLC reshapes gut microbiota, increasing beneficial bacteria and inhibiting harmful ones.
- The study provides a preclinical basis for carbon-based therapeutics in UC treatment.