Host macrophages/monocytes promote malaria transmission by modulating mosquito microbiota via SR-A-mediated phagocytosis - PubMed
5 hours ago
- #malaria
- #macrophages
- #transmission-blocking
- Host macrophages/monocytes enhance malaria transmission by modulating mosquito microbiota via SR-A-mediated phagocytosis.
- Macrophages/monocytes suppress growth of transmission-blocking bacteria like E. anophelis, S. sonnei, and K. oxytoca in the mosquito midgut.
- Depletion of macrophages/monocytes or use of anti-SR-A antibodies improves the efficacy of anti-Pfs25 monoclonal antibodies, blocking malaria transmission.
- The study suggests a new approach to inhibit malaria transmission by targeting SR-A to enhance the effectiveness of existing treatments.