p38MAPK protects against myocardial ischemia-reperfusion injury by regulating GLUT4 expression and translocation through MEF2A/MEF2C in isolated rat heart - PubMed
5 hours ago
- #Myocardial ischemia-reperfusion injury
- #p38MAPK
- #GLUT4
- p38MAPK protects against myocardial ischemia-reperfusion injury (MIRI) by regulating GLUT4 expression and translocation.
- MIRI suppresses p38MAPK activity and upregulates DUSP1/MKP1, leading to reduced GLUT4 expression and impaired glucose uptake.
- MEF2A and MEF2C, but not MEF2D, are downregulated during MIRI and play a critical role in restoring GLUT4 expression and membrane translocation.
- Overexpression of MEF2A or MEF2C enhances AS160 phosphorylation at specific sites, promoting Rab8a-GLUT4 vesicle association independently of AKT activation.
- The study identifies a p38MAPK-MEF2A/C-AS160-Rab8a signaling axis crucial for myocardial glucose uptake during MIRI.