DNA Polymerase Gamma Acetylation Governs Mitochondrial Homeostasis and Vascular Cell Senescence - PubMed
2 days ago
- #mitochondrial homeostasis
- #DNA polymerase gamma
- #vascular aging
- DNA polymerase gamma (Polγ) is crucial for mitochondrial DNA (mtDNA) replication and metabolism-associated senescence.
- Lysine acetylation at K1039 on Polγ is dynamically regulated during aging and affects mitochondrial function.
- Hyper-acetylation of Polγ K1039 reduces human aortic smooth muscle cell (HASMC) contractility and leads to hyperproliferation and mitochondrial dysfunction.
- D257A mutation in Polγ disrupts Sirt3-Polγ complex formation, leading to aberrant acetylation homeostasis and cellular senescence.
- Polγ acetylation at K1039 acts as a molecular switch for mtDNA homeostasis, HASMC functionality, and senescence progression.
- The findings provide insights into epigenetic-metabolic crosstalk in vascular aging and age-related pathologies.