Phosphorylation of PfiA modulates Pf4 phage production through PfiA/PfiT stoichiometric reconfiguration in Pseudomonas aeruginosa - PubMed
6 hours ago
- #phosphorylation
- #Pf4 phage
- #toxin-antitoxin system
- PfiA phosphorylation alters the stoichiometry of the PfiAT toxin-antitoxin complex.
- Phosphorylation converts the complex from PfiA6PfiT4 to PfiA2PfiT2, neutralizing toxin toxicity.
- This modification is mediated by kinase PfkA/PfkB from another prophage, Pf6.
- The change enables rapid Pf4 phage propagation during Pseudomonas aeruginosa biofilm development.
- The study reveals cross-talk between TA systems from different prophages via posttranslational modification.