Contribution of two-component regulatory systems to the acute-to-chronic infection transition of Pseudomonas aeruginosa in cystic fibrosis - PubMed
6 hours ago
- #two-component systems
- #cystic fibrosis
- #Pseudomonas aeruginosa
- Cystic fibrosis (CF) is a genetic disorder causing severe lung and digestive system dysfunction.
- Pseudomonas aeruginosa is a major pathogen in CF, leading to chronic respiratory infections and pulmonary decline.
- P. aeruginosa adapts to host defenses and antimicrobial treatments, transitioning from acute to chronic infections.
- Virulence factors like adhesins, proteases, and exotoxins aid in colonization, immune evasion, and disease progression.
- Environmental signals and adaptive mutations drive the transition to chronic infection, often leading to hypermutable phenotypes.
- Two-component regulatory systems play a key role in modulating gene expression and bacterial survival during infection.
- Understanding these mechanisms is crucial for developing new therapies against P. aeruginosa.