Mitochondrial vulnerability underlies myocarditis from COVID-19 mRNA vaccine - PubMed
18 hours ago
- #mRNA vaccine
- #myocarditis
- #mitochondria
- Mitochondrial vulnerability is linked to myocarditis caused by COVID-19 mRNA vaccines, particularly affecting young males.
- In a case-control study, patients with post-vaccination myocarditis showed mitochondrial abnormalities.
- In Polg+/D257A mice (with mitochondrial sensitivity), mRNA vaccination reduced left ventricular ejection fraction and induced cardiac immune cell infiltration.
- Bazedoxifene, an estrogen receptor modulator, prevented cardiac function decline in these mice, suggesting estrogen signaling's protective role.
- mRNA vaccination increased mitochondrial reactive oxygen species, activating RIPK3 (a necroptosis-related kinase) in cardiomyocytes.
- Mitochondrial vulnerability may be a risk factor for myocarditis via reactive oxygen species-mediated necroptosis signaling after mRNA vaccination.