Extracellular Vesicle-Mediated Precision Delivery of Paclitaxel Activates Mitophagy to Promote Repair after Spinal Cord Injury - PubMed
6 hours ago
- #mitophagy
- #spinal cord injury
- #extracellular vesicles
- Spinal cord injury (SCI) is a debilitating disorder with complex pathological processes leading to severe motor and sensory deficits.
- Existing therapies are insufficient for comprehensive functional restoration, necessitating alternative strategies.
- A novel nanoparticle-based drug delivery system was developed using extracellular vesicles (EVs) modified with an MMP-responsive peptide (ACPP) for targeted paclitaxel (PTX) delivery.
- The ACPP-EVs@PTX formulation combines EV drug-loading capacity, ACPP lesion-targeting, and PTX neuroprotective properties.
- Enhanced PTX accumulation at SCI lesions was achieved with reduced off-target distribution.
- In vitro and in vivo studies showed therapeutic efficacy via modulation of the SCI microenvironment, including angiogenesis stimulation, reduced inflammation, oxidative stress alleviation, and axonal regeneration promotion.
- Activation of PINK1-Parkin-mediated mitophagy improved mitochondrial function and neuronal repair.
- Behavioral evaluations confirmed significant neurological function recovery, highlighting translational potential.
- This work presents a multitarget, synergistic therapeutic strategy for spinal cord repair.