Multi-ancestry genome-wide association study of severe pregnancy nausea and vomiting - PubMed
5 hours ago
- #genome-wide association study
- #hyperemesis gravidarum
- #pregnancy nausea
- Identified ten genetic associations for hyperemesis gravidarum, including four previously known (GDF15, IGFBP7, PGR, GFRAL) and six new loci (SLITRK1, SYN3, IGSF11, FSHB, TCF7L2, CDH9).
- Found expression patterns: GDF15 and TCF7L2 primarily in extravillous trophoblasts, with opposing maternal-fetal genotype effects, while IGFBP7 and PGR were in maternal spiral arteries, limited to maternal genome.
- Linked selected loci to pregnancy outcomes like abnormal weight gain, duration, birth weight, and pre-eclampsia, and highlighted functional associations with genes like IGFBP7-AS1 and ACP1.
- Suggested candidate genes involve pathways related to appetite, insulin signaling, and brain plasticity, offering insights into etiology and potential therapies.