Molecular architecture of OXGR1 reveals an evolutionary conserved mechanisms for metabolite surveillance - PubMed
4 hours ago
- #GPCR
- #Structural Biology
- #Metabolite Sensing
- OXGR1 is a GPCR that senses metabolites like α-ketoglutarate and itaconate from the TCA cycle.
- Cryo-EM structures reveal a positively charged binding pocket with a hydrogen-bond network for selective dicarboxylic acid recognition.
- Hydrophobic residue arrangements modulate ligand potency and selectivity, and noncanonical motifs like FRY are essential for activation.
- Evolutionary analyses show conserved mechanisms, highlighting OXGR1's role in metabolic homeostasis and potential therapeutic applications.