PVNCRF Neurons Regulate Migraine-Like Allodynia by Activating CRFR2 on Spinal Trigeminal Caudalis Glutamatergic Neurons - PubMed
6 hours ago
- #CRF
- #migraine
- #neuroscience
- PVNCRF neurons in the hypothalamic paraventricular nucleus regulate migraine-like allodynia.
- Activation or inhibition of PVNCRF neurons mimics or blocks migraine-like allodynia, respectively.
- PVNCRF neurons excite glutamatergic neurons in the spinal trigeminal nucleus caudalis (SP5C).
- Excessive CRF release onto SP5CGlu neurons hyperactivates CRFR2, leading to hyperalgesia.
- Blockade of CRFR2 in the SP5C alleviates migraine-like allodynia.
- Clinical fMRI shows structural and functional alterations in PVN and SP5C regions in migraine patients.
- The study identifies a novel PVNCRF-SP5CGlu pathway in migraine, offering potential therapeutic targets.