NLRP1B is an integrated decoy that subverts Shigella flexneri E3 ligase activity to promote effector-triggered immunity - PubMed
5 hours ago
- #inflammasome
- #innate immunity
- #NLRP1B
- NLRP1B acts as an integrated decoy receptor in the immune system.
- It subverts Shigella flexneri E3 ligase activity to promote effector-triggered immunity.
- NLRP1B mimics host proteins targeted by pathogens, confusing pathogen effectors.
- Shigella flexneri E3 ligase IpaH7.8 recognizes both GSDMs and NLRP1B through a shared interface.
- NLRP1B presents a surface similar to GSDMs, acting as a decoy to promote inflammasome activation.
- This mechanism demonstrates the use of integrated decoy receptors by the vertebrate immune system.