Necroptotic cell death and immunomodulator release induced by T-cell engaging anti-lymphoma therapies - PubMed
4 hours ago
- #CAR-T
- #immunotherapy
- #necroptosis
- T-cell engaging therapies like bispecific antibodies and CAR T-cells induce necroptosis, not just apoptosis, in B-cell malignancies.
- Necroptosis involves proteins RIPK1, RIPK3, and MLKL and leads to release of immunomodulators such as HMGB1, IFN-y, IL-17, IL-6, IL-10, and IL1-RA.
- Modulating the balance between apoptosis and necroptosis in immunotherapy could impact the broader immune response against lymphoma.