Microglia-Derived Extracellular Vesicles from Alzheimer's Disease Patients Carry miRNAs Driving a Neuroinflammatory Response - PubMed
3 months ago
- #Alzheimer's disease
- #Neuroinflammation
- #Extracellular vesicles
- Microglia-derived extracellular vesicles (EVs) from Alzheimer's disease (AD) patients carry miRNAs that drive a neuroinflammatory response.
- EVs serve as intercellular messengers in the central nervous system (CNS) and are implicated in AD pathogenesis.
- TMEM119 antibody was used to immunocapture microglia-derived EVs from cerebrospinal fluid (CSF) of AD patients and control subjects.
- EVs from AD patients contained distinct disease-specific miRNA profiles, as assessed by small RNA sequencing.
- These miRNAs activate human TLR8, an RNA sensor, and induce TNF release from microglia, driving neuroinflammation.
- The study suggests that miRNAs in EVs could serve as biomarkers and therapeutic targets for AD.