An eye on metformin: Applications and drug delivery strategies for ocular conditions - PubMed
4 hours ago
- #Ocular Drug Delivery
- #Metformin
- #Drug Repurposing
- Metformin, an anti-hyperglycaemic agent, has pleiotropic effects showing potential for treating ocular conditions like inflammation, oxidative stress, burns, conjunctivitis, and neovascularization.
- Its high water solubility may limit effectiveness in conventional eye drops due to rapid dissolution in tear fluid and fast clearance, prompting the development of innovative delivery systems.
- Advanced ocular delivery strategies include in situ gels, polymeric films, and nanoparticles, which have proven effective in improving drug retention and therapeutic outcomes in ocular diseases.
- Organic cation transporters play a key role in facilitating metformin's trans-barrier movement in ocular tissues, offering a promising approach for non-invasive drug delivery.
- Further research and optimization of delivery systems are needed to overcome current barriers and enhance the clinical application of metformin for ocular treatments.