Emergence of Carbapenem-Resistant Escherichia coli Coharboring blaCTX-M-199 and Penicillin-Binding Protein 3 Insertion Conferring Increased Aztreonam/Avibactam Resistance in South China - PubMed
4 hours ago
- #CREC
- #ATM/AVI resistance
- #blaCTX-M-199
- Emergence of carbapenem-resistant Escherichia coli (CREC) coharboring blaCTX-M-199 and penicillin-binding protein 3 insertion in South China.
- 8.9% of CREC strains isolated in South China carried blaCTX-M-199, with 96.2% showing aztreonam/avibactam (ATM/AVI) nonsusceptibility.
- 38.5% of blaCTX-M-199-positive CREC strains were fully resistant to ATM/AVI.
- All blaCTX-M-199-positive strains harbored blaNDM-5 and YRIK/YRIN insertions, belonging to high-risk clones ST410 and ST167.
- blaCTX-M-199 can be located on the chromosome or transferable plasmids, contributing to reduced ATM/AVI susceptibility.
- The study highlights the need for monitoring blaCTX-M-199-harboring CREC and implementing its detection in clinical practice.