USP39 inhibits MLKL phosphorylation and deubiquitination to suppress necroptosis of nucleus pulposus cells and attenuate intervertebral disc degeneration - PubMed
6 hours ago
- #Necroptosis
- #Deubiquitination
- #Intervertebral disc degeneration
- USP39 inhibits MLKL phosphorylation and deubiquitination to suppress necroptosis in nucleus pulposus cells.
- MLKL phosphorylation is elevated in degenerative disc tissues and contributes to intervertebral disc degeneration (IVDD).
- USP39 overexpression reduces MLKL ubiquitination and phosphorylation, alleviating NP cell degeneration.
- Targeting the USP39-MLKL axis offers a potential therapeutic strategy for IVDD.
- The study provides insights for translational interventions in chronic low back pain.