Nonlinear association between triglyceride-glucose frailty index and new-onset stroke in adults at cardiovascular-kidney-metabolic syndrome stages 0-3: a CHARLS cohort study - PubMed
5 hours ago
- #frailty index
- #cardiovascular-kidney-metabolic syndrome
- #stroke risk
- The study examines the nonlinear association between the triglyceride-glucose frailty index and new-onset stroke in adults at cardiovascular-kidney-metabolic syndrome stages 0-3.
- A cohort of 6882 adults without stroke at baseline was analyzed, with 583 incident strokes (8.47% incidence) observed during follow-up.
- Stroke incidence increased with higher triglyceride-glucose frailty index tertiles: 5.14%, 8.24%, and 12.03% for low, middle, and high tertiles, respectively.
- Each 5-unit increase in the index was associated with a 1.46 higher hazard of stroke (95% CI: 1.31-1.64).
- The association was nonlinear, with an inflection point at an index value of 8.31, showing steeper risk increase below this level.
- Baseline cognitive function modified the association, with stronger effects in individuals with better cognitive function.
- Self-rated health and hypertension mediated approximately 23.0% and 7.6% of the association, respectively.
- The findings suggest that higher triglyceride-glucose frailty index is linked to increased stroke risk in this population, with nonlinearity and mediation effects.