Efficacy and Safety of Zonisamide Addition in Children With Developmental Epileptic Encephalopathy/Epileptic Encephalopathy: A Real-World Study - PubMed
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- #Zonisamide
- #Epileptic Encephalopathy
- #Real-World Study
- Zonisamide addition in children with DEE/EE showed responder rates around 51-55% and seizure-free rates of 24-28% over 12 months.
- Efficacy was sustained across ages and etiologies; predictors included female gender and fewer prior anti-seizure medications.
- In highly drug-resistant cases (≥5 prior medications), 44.3% responded and 20.0% achieved seizure freedom.
- The 12-month retention rate was 81.9%, with adverse events in 14.2% (e.g., reduced appetite at 7.9%), mostly tolerable.
- The study supports adjunctive zonisamide as effective and well-tolerated for refractory DEE/EE, including young children under 6.