Galvanin (TMEM154) is an electric-field sensor for directed cell migration - PubMed

4 hours ago

Galvanin (TMEM154) is identified as a sensor for electric-field-guided cell migration in immune and epithelial cells.
It relocalizes to the anodal side of cells in an electric field, with its extracellular domain's net charge driving this movement.
Expression of Galvanin can confer electric field responsiveness to non-responsive epithelial cells.
In human neutrophils, Galvanin relocalization precedes changes in cellular protrusion and retraction patterns.
The intracellular domain of Galvanin is crucial for its function, suggesting it transduces spatial electrical cues to the migratory apparatus.

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