Silent plaque ruptures in non-obstructive lesions of non-infarct-related arteries: a multimodality, serial intracoronary imaging study - PubMed
3 days ago
- #Intracoronary imaging
- #Plaque rupture
- #Non-culprit lesion
- Plaque rupture occurs in non-obstructive lesions of non-infarct-related arteries (non-IRAs) without causing ischemia.
- Study assessed frequency, characteristics, and morphological changes of plaque rupture in non-IRAs of AMI patients over 52 weeks.
- Plaque rupture was observed in 12% of AMI patients (41 lesions in 40 patients).
- Lesions with rupture had larger percent atheroma volume, larger external elastic membrane area, and thinner fibrous caps.
- 51% of untreated ruptures healed by 52 weeks, with thin-cap fibroatheroma being the most frequent baseline morphology for new-onset ruptures.
- Larger plaque volume, positive remodeling, and thinner fibrous caps were associated with plaque rupture.