Senescent obesity signature in breast cancer: a paradigm of reverse cardio-oncology - PubMed
5 hours ago
- #Obesity
- #Breast Cancer
- #Cardio-oncology
- Reverse cardio-oncology explores how cardiometabolic issues like obesity increase breast cancer risk and affect tumor biology.
- Traditional obesity measures like BMI are limited; refined phenotypes such as metabolically unhealthy obesity better stratify breast cancer risk.
- Senescent adipose tissue drives breast tumor changes via the senescence-associated secretory phenotype (SASP), epigenetic shifts, and immunosenescence.
- Potential interventions include lifestyle changes, cardiometabolic drugs (e.g., GLP-1 agonists, SGLT2 inhibitors), and senolytic therapies.
- This approach integrates cardiovascular and oncologic care for prevention and treatment in at-risk women.