Post hoc estimation of a quantitative restriction spectrum imaging biomarker for prostate cancer detection using conventional MRI - PubMed
7 hours ago
- #MRI
- #diffusion imaging
- #prostate cancer
- Multiparametric MRI is useful for early detection of clinically significant prostate cancer (csPCa), but standard ADC has limited utility.
- Restriction spectrum imaging (RSI) provides a quantitative biomarker (RSIrs) that improves csPCa detection.
- Study evaluates post hoc estimation of RSI metrics from conventional DWI as a surrogate for dedicated RSI acquisition.
- Three RSI restriction score (RSIrs) calculation methods compared: dedicated acquisition, conventional DWI alone, and a combination.
- Post hoc RSIrsmax showed systematic differences from RSIrsdedicated but still outperformed ADC in csPCa detection.
- AUCs for csPCa detection were highest for RSIrsdedicated, followed by RSIrscombo, RSIrspost-hoc, and ADC.
- RSIrs, even estimated from conventional DWI, is superior to ADC for automated, patient-level csPCa detection.
- Best performance comes from a dedicated RSI acquisition; a compromise is acquiring high b-values to complement conventional DWI.